2022
Tavarekere, et al. Unaffected ex vivo clotting cascade by experimental hemostatic nanoparticles when introduced in presence of recombinant tissue plasminogen activator, Brain Circulation.
S. Menikheim, J. Leckron, M. Duffy, M. Zupan, A. Mallory, W. Lien and E. Lavik, Biocompatible Nanocapsules for Self-Healing Dental Resins and Bone Cements. ACS Omega: p. 2022.
Maisha, N., Kulkarni, C., Zilberberg, R., Pandala, N., Schaub, L. Neidert, L., Glaser, J., Cannon, J., Janeja, V., Lavik, E. PEGylated Polyester Nanoparticles Trigger Adverse Events in a Large Animal Model of Trauma and in Naïve Animals: Understanding Cytokine and Cellular Correlations with These Events. ACS Nano, 2022.
B. Mahaling, N. Pandala, H-C Wang, and E. Lavik. Azithromycin protects retinal glia against oxidative stress-induced morphological changes, inflammation, and cell death, ACS Bio & Med Chem Au, Accepted.
C. Riahin, A. Meares, N. N. Esemoto, M. Ptaszek, M. LaScola, N. Pandala, E. Lavik, M. Yang, G. Stacey, D. Hu, J. C. Traeger, G. Orr and Z. Rosenzweig, Hydroporphyrin-Doped Near-Infrared-Emitting Polymer Dots for Cellular Fluorescence Imaging. ACS Applied Materials & Interfaces: 2022.
N. Pandala, M. A. LaScola, Z. Hinton, L. T. J. Korley and E. Lavik, Finding the sweet spot: a library of hydrogels with tunable degradation for tissue model development. Journal of Materials Chemistry B, accepted, 2022.
2021
N. Maisha, M. Rubenstein, C. J. Bieberich and E. Lavik, Getting to the Core of It All: Nanocapsules to Mitigate Infusion Reactions Can Promote Hemostasis and Be a Platform for Intravenous Therapies. Nano Letters, 2021.
N. Pandala, M. A. LaScola, Y. Tang, M. Bieberich, L. T. J. Korley and E. Lavik, Screen Printing Tissue Models Using Chemically Cross-Linked Hydrogel Systems: A Simple Approach To Efficiently Make Highly Tunable Matrices. ACS Biomaterials Science & Engineering, 2021.
Posey, J.; Lavik, E. Storytelling for Social Justice: A Materials Science Class. Journal of Chemical Education, 2021.
Maisha, Nuzhat; Naik, Nidhi; Okesola, Mawuyon; Coombs, Tobias; Lavik, Erin; Engineering PEGylated polyester nanoparticles to reduce complement-mediated infusion reaction, Bioconjugate Chemistry, 2021.
Mahaling, B., Baruah, N., Ahamad, N., Maisha, N., Lavik, E. and Katti, D. S., A non-invasive nanoparticle-based sustained dual-drug delivery system as an eyedrop for endophthalmitis. Int J Pharm, 606: p. 120900. 2021.
Onyeje, C. and Lavik, E., Highlighting the Usage of Polymeric Nanoparticles for the Treatment of Traumatic Brain Injury: A Review Study. Neurochemistry International: p. 105048. 2021.
2020
Pandala, N., Haywood, S., LaScola, M. A., Day, A., Leckron, J. and Lavik, E., Screen Printing to Create 3D Tissue Models. ACS Applied Bio Materials. 2020.
Menikheim, S., Leckron, J., Bernstein, S. and Lavik, E. B., On-Demand and Long-Term Drug Delivery from Degradable Nanocapsules. ACS Applied Bio Materials. 2020.
Lavik, E., Thermo in the Time of COVID-19: Using Improvisation to Foster Discussion and Translating the Experience to Online Learning. Biomedical Engineering Education. 2020.
Maisha, N., Coombs, T. and Lavik, E., Development of a Sensitive Assay to Screen Nanoparticles in vitro for Complement Activation. ACS Biomater Sci Eng. 2020.
Menikheim, S. and Lavik, E. Self-Healing Biomaterials: the Next Generation is Nano. WIREs: Nanomedicine and Nanobiotechnology, 2020.
2019
Bolger, M., Groynom, R., Bogie, K., Lavik, E. Reporter Scaffolds for Clinically Relevant Cell Transplantation Studies, Annals of Biomedical Engineering, 2019.
Brown, A. C., Lavik, E. and Stabenfeldt, S. E., Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen. Bioconjug Chem, 30(7): p. 1951-1956. 2019.
2018
Onwukwe, C., Maisha, N., Holland, M., Varley, M., Groynom, R., Hickman, D., Uppal, N., Shoffstall, A., Ustin, J. and Lavik, E., Engineering Intravenously Administered Nanoparticles to Reduce Infusion Reaction and Stop Bleeding in a Large Animal Model of Trauma. Bioconjug Chem. 2018.
Fernandez-Moure, J., Maisha, N., Lavik, E. B. and Cannon, J., The chemistry of lyophilized blood products. Bioconjug Chem. 2018.
2017
Hubbard, W. B., Greenberg, S., Norris, C., Eck, J., Lavik, E. and VandeVord, P., Distinguishing the Unique Neuropathological Profile of Blast Polytrauma. Oxidative Medicine and Cellular Longevity, 2017: p. 11. 2017.
van Hest, J., Lavik, E. B., Smith, B. D., Zheng, G. and Rotello, V. M., Science in a Global Community. Bioconjug Chem, 28(2): p. 279-281. 2017.
2016
Lavik, E., Kuehn, M. H., Shoffstall, A., Atkins, K., Dumitrescu, A. V. and Kwon, Y. H., Sustained Delivery of Timolol Maleate for over 90 days via Subconjunctival Injection. Journal of Ocular Pharmacology and Therapeutics. accepted.
Lashof-Sullivan, M., Holland, M., Groynom, R., Campbell, D., Soffstall, A. and Lavik, E. B., Hemostatic Nanoparticles Improve Survival Following Blunt Trauma Even after 1 Week Incubation at 50 degrees C. ACS Biomaterials Science & Engineering. 2016.
Szeto, G. L. and Lavik, E., Materials design at the interface of nanoparticles and innate immunity. Journal of Materials Chemistry B. 2016.
van Hest, J., Lavik, E. B., Smith, B. D., Zheng, G. and Rotello, V., Editorial. Bioconjug Chem, 27(1): p. 1-2. 2016.
2015
R. Groynom, L. Wu, E. Shoffstall, and E.B. Lavik. Controlled release of photoswitch drugs by PLGA microsphere encapsulation, Journal of Drug Targeting, 4(4): p. 387-391. 2015.
Hubbard, WB, Lashof-Sullivan, M, Sajja, VS, Lavik, E, and VandeVord, P. Addition of Dexamethasone to Hemostatic Nanoparticles Combats Pulmonary Hemorrhaging after Primary Blast Lung Injury, ACS Macro Letters, accepted.
Ssuneki, M., Hardee, S., Michaud, M., Morotti, R., Lavik, E., Madri, J. A Hydrogel-Endothelial Cell implant Mimics Infantile Hemangioma: Modulation by Survivin and the Hippo pathway, Laboratory Investigation, 2015.
Sethi, R., Sethi, R., Redmond, A. and Lavik, E. B., Olfactory Ensheathing Cells Promote Differentiation of Neural Stem Cells and Robust Neurite Extension, Stem Cells Reviews and Reports, in press.
van Hest, J., Lavik, E. B., Smith, B. D., Zheng, G. and Rotello, V., Editorial. Bioconjug Chem. 2015.
2014
Lashof-Sullivan, Shoffstall, E., Atkins, K., Keane, N., Bir, C., VandeVord, P., Lavik, E. Intravenously Administered Nanoparticles Increase Survival Following Blast Trauma. Proceedings of the National Academy of Sciences, in press.
Sethi, R., Sethi, R., Redmond, A. and Lavik, E. B., Olfactory Ensheathing Cells Promote Differentiation of Neural Stem Cells and Robust Neurite Extension, Stem Cells Reviews and Reports, in press.
Hubbard, WB, Hall, C, Sajja, VS, Lavik, E, and VandeVord, P. Examining lethality risk for rodent studies of primary blast lung injury. Biomed Sci Instrum. 2014.
2013
Lashof-Sullivan, M., Shoffstall, A. and Lavik, E., Intravenous hemostats: challenges in translation to patients. Nanoscale, 5(22): p. 10719-28. 2013.
Shoffstall, A. J., Everhart, L. M., Varley, M. E., Soehnlen, E. S., Shick, A. M., Ustin, J. S. and Lavik, E. B., Tuning Ligand Density on Intravenous Hemostatic Nanoparticles Dramatically Increases Survival Following Blunt Trauma. Biomacromolecules. 2013.
Hertz, J., Robinson, R., Valenzuela, D. A., Lavik, E. B. and Goldberg, J. L., A tunable synthetic hydrogel system for culture of retinal ganglion cells and amacrine cells. Acta Biomater, 9(8): p. 7622-9. 2013.
Kador, K. E., Montero, R. B., Venugopalan, P., Hertz, J., Zindell, A. N., Valenzuela, D. A., Uddin, M. S., Lavik, E. B., Muller, K. J., Andreopoulos, F. M. and Goldberg, J. L., Tissue engineering the retinal ganglion cell nerve fiber layer. Biomaterials, 34(17): p. 4242-50. 2013.
2012
Williams, C., Rauch, M., Michaud, M., Robinson, R., Xu, H., Madri, J. A. and Lavik, E. B., Neural Progenitor Cells Modify the In Vivo Formation of Engineered Vascular Networks. PLOS One. In press.
Shoffstall, A. J., Atkins, K. T., Groynom, R. E., Varley, M. E., Everhart, L. M., Lashof-Sullivan, M. M., Martyn-Dow, B., Butler, R. S., Ustin, J. S. and Lavik, E. B., Intravenous hemostatic nanoparticles increase survival following blunt trauma injury. Biomacromolecules, 13(11): p. 3850-7. 2012.
Lavik, E. and Ustin, J., Medicine. Leveraging shear stress to bust clots with nanoparticles. Science, 337(6095): p. 658-9. 2012.
Lavik, E., Bioengineering approaches to nervous system repair. Neurosci Lett, 519(2): p. 85-6. 2012.
Lavik, E. B., Kuppermann, B. D. and Humayun, M. S., Drug Delivery, in Retina, S. J. Ryan, Editor. in press.
Shoffstall, A. J., Taylor, D. M. and Lavik, E. B., Engineering therapies in the CNS: what works and what can be translated. Neurosci Lett, 519(2): p. 147-54. 2012.
2011
Robinson, R., Viviano, S., Criscione, J., Williams, C., Jun, L., Tsai, J. and Lavik, E. B., Nanospheres delivering the EGFR TKI AG1478 promote optic nerve regeneration: the role of size for intraocular drug delivery. ACS Nano, in press. pdf
Lavik, E. and von Recum, H., The role of nanomaterials in translational medicine. ACS Nano, 5(5): p. 3419-24. 2011. pdf
Lavik, E., Kuehn, M. H. and Kwon, Y. H., Novel drug delivery systems for glaucoma. Eye (Lond), 25(5): p. 578-86. 2011. pdf
Lavik, E. B., Neural Tissue Engineering, in Biomaterials for Tissue Engineering: A Review of the Past and Future Trends, J. A. Burdick and R. L. Mauck, Editors. 2011, Springer-Wien: New York.
2010
Lavik, E. B. and Madri, J. A., Angiogenesis, the neurovascular niche and neuronal reintegration after Injury, in Therapeutic angiogenesis for vascular diseases: Molecular mechanisms and targeted clinical approaches for the treatment of angiogenic disease, M. Slevin, Editor. 2010, Springer: London.
Hynes, S. R. and Lavik, E. B., A tissue-engineered approach towards retinal repair: scaffolds for cell transplantation to the subretinal space. Graefes Arch Clin Exp Ophthalmol, 248(6): p. 763-78. 2010. pdf
Tzeng, S. F. and Lavik, E. B., Photopolymerizable nanoarray hydrogels delivery CNTF and promote differentiation of neural stem cells. Soft Mater, 6: p. 2208-2215. 2010. pdf
Bertram, J., Rauch, M. F., Chang, K. and Lavik, E. B., Using polymer chemistry to modulate the delivery of neurotrophic factors from degradable microspheres: Delivery of BDNF. Pharmaceutical Research, 2010.
R. Robinson, J. Bertram, J. L. Reiter and E. B. Lavik, New platform for controlled and sustained delivery of EGFR tyrosine kinase inhibitors using PLGA microspheres. Journal of Microencapsulation, 2010.
2009
Bertram, J., Williams, C., Robinson, R., Segal, S. S., Flynn, N. T. and Lavik, E., Intravenous Hemostat: Nanotechnology to Halt Bleeding. Science Translational Medicine, 1(11). 2009.
C. Williams and E. Lavik, Engineering the CNS stem cell microenvironment. Regenerative Medicine, 4 (6) 865-77. 2009.
M. Kyhn, H. Klassen, U. Johansson, K. Warfvinge, E. Lavik, J. Kiilgaard, J. Prause, E. Scherfig, M. Young and M. la Cour, Delayed administration of glial cell line-derived neurotrophic factor (GDNF) protects retinal ganglion cells in a pig model of acute retinal ischemia. Experimental Eye Research, epub. 2009.
J. Bertram, S. M. Jay, S. R. Hynes, R. Robinson and E. B. Lavik, Functionalized poly(lactic-co-glycolic acid): a versatile biomaterial for drug delivery and tissue engineering without compromising biocompatibility. Acta Biomat., 5(8) 2860-71. 2009.
Rauch, M. F., Hynes, S. R., Bertram, J., Redmond, A., Robinson, R., Williams, C., Xu, H., Madri, J. A. and Lavik, E. B., Engineering angiogenesis following spinal cord injury: A coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood-spinal cord barrier. European Journal of Neuroscience, 29(1): p. 132-145. 2009.
Bertram, J.*, Saluja, S. S.*, McKain, J. A. and Lavik, E. B., Sustained Delivery of Timolol Maleate from Poly(lactic-co-glycolic acid)/Poly(lactic acid) Microspheres for over 3 months. Journal of Microencapsulation, 26(1): p. 18-26. 2009. *contributed equally
2008
Tzeng, S., Nkansah, M., Holdt, A. M. and Lavik, E., Sustained delivery of CNTF from polymer nano- and microspheres for neural differentiation and neuroprotection. Biotechnology and Bioengineering, 100(5): p. 1010-1019. 2008.
Hynes, S. R., Rauch, M. F., Bertram, J. and Lavik, E. B. A library of tunable poly(ethylene glycol)/poly-L-lysine hydrogels to investigate the materials cues that influence neural stem cell differentiation. Journal of Biomedical Materials Research Part A, epub 2008.
Rauch, M. F., Michaud, M., Xu, H., Madri, J. A. and Lavik, E. B., Coculture of primary neural progenitor and endothelial cells in a synthetic, degradable macroporous gel promotes stable vascular networks in vivo. Journal of Biomaterials Science-Polymer Edition, 19(11): p. 1469-1485. 2008.
2007
Ng, T. F., Lavik, E., Keino, H., Taylor, A. W., Langer, R. S. and Young, M. J. Creating an immune-privileged site using retinal progenitor cells and biodegradable polymers. Stem Cells 25: 1552-1559, 2007.
Hynes, S. R., McGregor, L. and Lavik, E. B. Photopolymerizable hydrogels for neural tissue engineering. Journal of Biomedical Materials Science: Polymer Edition 18: 1017-1030, 2007.
Ward, M. S., Khoobehi, A., Lavik, E. B., Langer, R. and Young, M. J. Neuroprotection of retinal ganglion cells in DBA/2J mice with GDNF-loaded biodegradable microspheres. Journal of Pharmaceutical Sciences 96: 558-568, 2007.
Talbott, J. F., Cao, Q. L., Bertram, J., Nkansah, M., Benton, R. L., Lavik, E. and Whittemore, S. R. CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Experimental Neurology 204: 485-489, 2007.
2006
Li, Q., Ford, M. C., Lavik, E. B. and Madri, J. A. Modeling the neurovascular niche: VEGF and BDNF-mediated cross-talk between neural stem cells and endothelial cells: An in vitro study. Journal of Neuroscience Research 84: 1656-1668, 2006.
Ford, M. C., Bertram, J. P., Hynes, S. R., Michaud, M., Li, Q., Young, M., Segal, S. S., Madri, J. A. and Lavik, E. B. A macroporous hydrogel for the co-culture of neural progenitor and endothelial cells to form functional vascular networks in vivo. Proceedings of the National Academy of Sciences of the United States of America, 103: 2512-2517, 2006.
2005
Lavik, E. and Langer, R. Nerve Regeneration. In: P. X. Ma and J. H. Elisseeff, eds. Scaffolding in Tissue Engineering. Boca Raton, FL: Taylor&Francis, 2005.
Tomita, M., Lavik, E., Klassen, H., Zahir, T., Langer, R., Young, M.J. Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells. Stem Cells, 23: 1579-1588, 2005.
Anderson, D.G., Putnam, D., Lavik, E. B., Mahmood, T., and Langer, R. Biomaterial Microarrays: Rapid, Microscale Screening of Polymer-Cell Interaction. Biomaterials, 26: 4892-4897, 2005.
Warfvinge, K., Kiilgaard, J.F., Lavik, E., Scherfig, E., Langer, R., Klassen, H., Young, M. J. Retinal progenitor cell xenografts to the pig retina: morphological integration and cytochemical differentiation. Archives of Ophthalmology, 123: 1385-1393, 2005.
Lavik, E. B., Klassen, H., Warfvinge, K., Langer, R. Young, M. J. Fabrication of a Novel Degradable Polymer Scaffold to Direct the Integration and Differentiation of Retinal Progenitors in Models of Retinal Degeneration. Biomaterials, 26: 3187-3196, 2005.
2004
Lavik, E. B., and Langer, R. S. Tissue Engineering: Current State and Perspectives, Applied Microbiology and Biotechnology, 65: 1-8, 2004.
2003
Levenberg, S. Huang, N. F., Lavik, E. B., Rogers, A. Itskovitz-Eldor, J. and Langer, R. Engineering Three-Dimensional Tissue Structures Using Differentiating Human Embryonic Stem Cells, Proc. Nat. Acad. Sci. 100: 12741-12746, 2003.
2002
Teng, Y. D. *, Lavik, E. B.*, Qu, X., Park, K. I., Ourednik, J., Zurakowski, D., Langer, R., Snyder, E. Y. Functional Recovery Following Traumatic Spinal Cord Injury Mediated by a Unique Polymer Scaffold Seeded with Neural Stem Cells, Proc. Nat. Acad. Sci. 99: 3024-3029, 2002. *co-first authors.
2001
Lavik, E. B., Teng, Y. D., Snyder, E. Y., Langer, R. Seeding Neural Stem Cells on Scaffolds of PGA, PLA and Their Copolymers in Methods in Molecular Medicine, Neural Stem Cells: Methods and Protocols, 2001.
Lavik, E. B., Hrkach, J. S., Lotan, N., Nazarov, R. Langer, R. A Simple Synthetic Route to the Formation of a Block Copolymer of Poly(lactic-co-glycolic acid) and Polylysine for the Fabrication of Functionalized, Degradable Structures for Biomedical Applications, J. of Biomed. Mat. Res. 58: 291-294, 2001.
1997
Chiang, Y. -M., Lavik, E. B., Kosacki, I, Tuller, H. L. and Ying, J. Y. Nonstoichiometry and Electrical Conductivity of Nanocrystalline CeO2-x, J. Electroceram., 1: 7-14, 1997.
Chiang, Y. -M., Lavik, E. B., and Blom, D. A. “Defect Thermodynamics and Electrical Properties of Nanocrystalline Oxides: Pure and Doped CeO2”, Nanostructured Materials, 9: 633-642, 1997.
Chiang, Y. -M., Lavik, E. B., Kosacki, I., Tuller, H. L., and Ying, J. Y. Defect and Transport Properties of Nanocrystalline CeO2-x. Appl. Phys. Lett. 69 185-187, 1996.
Lavik Lab 