Figure 1: (a) Hemostatic nanoparticles. The particles contain a poly(lactic-co-glycolic acid) (PLGA) core functionalized with poly(ethylene glycol) (PEG) arms and RGD-based peptides that target the glycoprotein IIIb/IIa receptors on activated platelets. (b) SEM of liver clot pseudocolored to show blood cells (red), hemostatic nanoparticles (green) and the fibrin mesh that is critical for clot stability. (c) Survival at 1 hour post injury. The hemostatic nanoparticles (GRGDS) significantly improve survival compared to the saline injury control.
Our paper, on the use of synthetic platelets to stop bleeding in a model of blunt trauma was just accepted at Biomacromolecules. Congratulations to all of the authors!
Shoffstall, A., Atkins, K., Groynom, R., Varley, M., Everhart, L., Lashof-Sullivan, M., Martyn-Dow, B., Butler, R., Ustin, J., Lavik, E. Intravenous Hemostatic Nanoparticles Increase Survival Following Blunt Trauma Injury. Biomacromolecules. In press.
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